der Alzheimer-Krankheit

C60 may possibly help in the treatment of Alzheimer's disease. Research has shown how C60 has the potential to prevent, slow down and even reverse the degenerative processes that occur in the brain during dementias such as Alzheimer's.

Psychische Verschlechterung durch Alzheimer-KrankheitPsychische Verschlechterung durch Alzheimer-Krankheit

In 2017 the WHO reported that around 50 million people worldwide were suffering from dementia and that 60-70% of those cases were as a result of Alzheimer's disease. Indeed Alzheimer’s Disease International project this could rise to over 130 million by 2050. The loss of memory and independence due to dementia has serious implications for suffers, their families and health systems. Treatments that could prevent, slow and reverse the development of Alzheimer's disease over help for millions.

During the development of Alzheimer’s disease there is a build-up of amyloid-β protein fibrils outside the neurons (nerve cells) in the brain. Amyloids are normally found in the body but for some reason they may accumulate in the brain and form a sticky build up; an amyloid plaque. These amyloid plaques along with neurofibrillary tangles are thought to contribute to the degradation of the neurons in the brain and the subsequent symptoms of Alzheimer's disease.

In 2012 researchers have shown, using computer simulations, that C60 is able to destabilise the structure of the amyloid-β protein and prevent the formation of the amyloid plaques [1]. The hope is for C60 slowing or reversing Alzheimer's disease. Another group were able, using electron microscopy, to photograph the C60 molecules preventing the formation of amyloid fibrils and so C60 might prevent Alzheimer's disease. They also showed that a polycarboxyl derivative of C60 destroyed mature amyloid fibrils of muscle protein and prevented formation of new fibrils [2]. A further studied showed C60 had neuroprotective effects on the brain [3]. In studies on a strain of mice which develops dementia, showed those given C60 were able to remember their way round a maize whilst those not given it lost their spatial memory with age. The mice given C60 also had increased their life duration [4]

The references quoted here and elsewhere suggest that C60 could play a role in treating forms of dementia including Alzheimer’s disease. We have customers of ours who on starting C60 have remarked how their concentration is better.

[1] Amyloid-β fibril disruption by C60-molecular guidance for rational drug design.

[2] Fullerenes C60, antiamyloid action, the brain, and cognitive processes.;

[3]&nbspNeuroprotective effects of hydrated fullerene C60: cortical and hippocampal EEG interplay in an amyloid-infused rat model of Alzheimer's disease.

[4] Neurobiology of Aging 29 (2008) 117–128 A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice.